Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor

Federico Miozzo; Eva P. Valencia-Alarcón; Luca Stickley; Michaëla Majcin Dorcikova; Francesco Petrelli; Damla Tas; Nicolas Loncle; Irina Nikonenko; Peter Bou Dib; Emi Nagoshi

doi:10.1038/s41467-022-29075-0

Nature Communications (Mar 2022)

Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor

Federico Miozzo,
Eva P. Valencia-Alarcón,
Luca Stickley,
Michaëla Majcin Dorcikova,
Francesco Petrelli,
Damla Tas,
Nicolas Loncle,
Irina Nikonenko,
Peter Bou Dib,
Emi Nagoshi

Affiliations

Federico Miozzo: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Eva P. Valencia-Alarcón: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Luca Stickley: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Michaëla Majcin Dorcikova: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Francesco Petrelli: Department of Cell Biology, University of Geneva
Damla Tas: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Nicolas Loncle: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva
Irina Nikonenko: Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva
Peter Bou Dib: Institute of Cell Biology, University of Bern
Emi Nagoshi: Department of Genetics and Evolution and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva

DOI: https://doi.org/10.1038/s41467-022-29075-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Mitochondrial dysfunction in dopaminergic neurons is a pathological hallmark of Parkinson’s disease. Here, the authors find a conserved mechanism by which a single transcription factor controls mitochondrial health in dopaminergic neurons during the aging process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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