Nature Communications (Sep 2021)
Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
- Ah-Lai Law,
- Shamsinar Jalal,
- Tommy Pallett,
- Fuad Mosis,
- Ahmad Guni,
- Simon Brayford,
- Lawrence Yolland,
- Stefania Marcotti,
- James A. Levitt,
- Simon P. Poland,
- Maia Rowe-Sampson,
- Anett Jandke,
- Robert Köchl,
- Giordano Pula,
- Simon M. Ameer-Beg,
- Brian Marc Stramer,
- Matthias Krause
Affiliations
- Ah-Lai Law
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Shamsinar Jalal
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Tommy Pallett
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Fuad Mosis
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Ahmad Guni
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Simon Brayford
- Stramer Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Lawrence Yolland
- Stramer Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Stefania Marcotti
- Stramer Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- James A. Levitt
- Ameer-Beg Group, Richard Dimbleby Cancer Research Laboratories, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King’s College London
- Simon P. Poland
- Ameer-Beg Group, Richard Dimbleby Cancer Research Laboratories, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King’s College London
- Maia Rowe-Sampson
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Anett Jandke
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Robert Köchl
- School of Immunology and Microbial Sciences, King’s College London
- Giordano Pula
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Simon M. Ameer-Beg
- Ameer-Beg Group, Richard Dimbleby Cancer Research Laboratories, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King’s College London
- Brian Marc Stramer
- Stramer Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- Matthias Krause
- Krause Group, Randall Centre for Cell and Molecular Biophysics, King’s College London
- DOI
- https://doi.org/10.1038/s41467-021-25916-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complexes, cell protrusion stability, and cell migration.
