Fe3O4@SiO2@ADMPT/H6P2W18O62: a novel Wells–Dawson heteropolyacid-based magnetic inorganic–organic nanohybrid material as potent Lewis acid catalyst for the efficient synthesis of 1,4-dihydopyridines

Abstract

A novel Wells–Dawson heteropolyacid-based magnetic Inorganic–organic nanohybrid, Fe3O4@SiO2@ADMPT/H6P2W18O62, was fabricated and used as a green, efficient, eco-friendly, and highly recyclable catalyst for the one-pot and multi-component synthesis of 1,4-Dihydopyridine (1,4-DHP) derivatives from the reaction of various aromatic aldehydes with ethyl acetoacetate and ammonium acetate with good to excellent yields and in a short span of time. The nanohybrid catalyst was prepared by the chemical anchoring of Wells–Dawson heteropolyacid H6P2W18O62 onto the surface of functionalized Fe3O4 nanoparticles with 2,4-bis(3,5-dimethylpyrazol)-triazine (ADMPT) linker. These nanocatalysts were identified by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and vibrating sample magnetometer (VSM). This protocol is developed as a safe, cost-effective and convenient alternate method for the synthesis of 1,4-DHP derivatives utilizing an eco-friendly, and a highly reusable catalyst.

Keywords

• Wells–Dawson heteropolyacid
• eco-friendly catalyst
• 1,4-dihydopyridine
• Hantzsch reaction
• fe3O4 nanoparticles
• green chemistry