Communications Biology (Mar 2021)
Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
Abstract
Mohammad et al. show that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions in mice. They find that S. aureus Lpp promotes abscess formation, which protects bacteria from innate immune killing, suggesting an intriguing bacterial immune evasion mechanism.