Communications Biology (Mar 2021)

Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing

  • Majd Mohammad,
  • Manli Na,
  • Zhicheng Hu,
  • Minh-Thu Nguyen,
  • Pradeep Kumar Kopparapu,
  • Anders Jarneborn,
  • Anna Karlsson,
  • Abukar Ali,
  • Rille Pullerits,
  • Friedrich Götz,
  • Tao Jin

DOI
https://doi.org/10.1038/s42003-021-01947-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Mohammad et al. show that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions in mice. They find that S. aureus Lpp promotes abscess formation, which protects bacteria from innate immune killing, suggesting an intriguing bacterial immune evasion mechanism.