Case Reports in Neurology (Dec 2016)

Early Motor Fluctuations in a Patient with Striatonigral Degeneration

  • Fumihito Yoshii,
  • Yusuke Moriya,
  • Tomohide Ohnuki,
  • Wakoh Takahashi,
  • Masafuchi Ryo

DOI
https://doi.org/10.1159/000453254
Journal volume & issue
Vol. 8, no. 3
pp. 243 – 250

Abstract

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We report a 44-year-old female with striatonigral degeneration (SND) who showed wearing-off oscillations after 4 months of levodopa treatment. The patient presented with asymmetric left-side dominant rigidity, and levodopa was effective at first. However, she began to show wearing-off oscillations of motor symptoms, which gradually worsened thereafter. Fluid-attenuated inversion recovery sequence magnetic resonance imaging (MRI) showed linear lateral putamen hyperintensities, and positron emission tomography (PET) studies using 18F-fluorodopa (FD) and 11C-N-methylspiperon (NMSP) showed a marked decrease of radioactivity in the right putamen, especially in the posterior putamen. The results of MRI and 2 PET studies with FD and NMSP were well consistent with the diagnosis of SND.

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