Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study

Abstract

Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs.

Keywords

• association
• diplotype
• genetic association
• genetics
• haplotype
• neuregulin-1
• nrg1
• schizophrenia
• snp