Nature Communications (Nov 2018)
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
- Isabelle Cambré,
- Djoere Gaublomme,
- Arne Burssens,
- Peggy Jacques,
- Nadia Schryvers,
- Amélie De Muynck,
- Leander Meuris,
- Stijn Lambrecht,
- Shea Carter,
- Pieter de Bleser,
- Yvan Saeys,
- Luc Van Hoorebeke,
- George Kollias,
- Matthias Mack,
- Paul Simoens,
- Rik Lories,
- Nico Callewaert,
- Georg Schett,
- Dirk Elewaut
Affiliations
- Isabelle Cambré
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Djoere Gaublomme
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Arne Burssens
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Peggy Jacques
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Nadia Schryvers
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Amélie De Muynck
- UGCT-Department of Physics and Astronomy, Ghent University
- Leander Meuris
- Unit of Medical Biotechnology, VIB Inflammation Research Center (IRC), VIB
- Stijn Lambrecht
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- Shea Carter
- Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
- Pieter de Bleser
- Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research
- Yvan Saeys
- Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research
- Luc Van Hoorebeke
- UGCT-Department of Physics and Astronomy, Ghent University
- George Kollias
- Division of Immunology, Biomedical Sciences Research Center ‘Alexander Fleming’
- Matthias Mack
- Deparment of Internal Medicine II – Nephrology, University Hospital Regensburg
- Paul Simoens
- Department of Morphology, Faculty of Veterinary Medicine, Ghent University
- Rik Lories
- Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
- Nico Callewaert
- Unit of Medical Biotechnology, VIB Inflammation Research Center (IRC), VIB
- Georg Schett
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg and Universitatsklinikum
- Dirk Elewaut
- Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC)
- DOI
- https://doi.org/10.1038/s41467-018-06933-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclast to contribute this tissue specificity.
