Nature Communications (Sep 2022)
Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells
- Sarah Tessier,
- Omar Ferhi,
- Marie-Claude Geoffroy,
- Román González-Prieto,
- Antoine Canat,
- Samuel Quentin,
- Marika Pla,
- Michiko Niwa-Kawakita,
- Pierre Bercier,
- Domitille Rérolle,
- Pierre Therizols,
- Emmanuelle Fabre,
- Alfred C. O. Vertegaal,
- Hugues de Thé,
- Valérie Lallemand-Breitenbach
Affiliations
- Sarah Tessier
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Omar Ferhi
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Marie-Claude Geoffroy
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Román González-Prieto
- Department of Cell and Chemical Biology, Leiden University Medical Center (LUMC)
- Antoine Canat
- Université Paris Cité, Inserm, CNRS, GenCellDis, Institut de Recherche Saint-Louis
- Samuel Quentin
- Université Paris Cité, Inserm, CNRS, GenCellDis, Institut de Recherche Saint-Louis
- Marika Pla
- Normal and pathological hematopoiesis: Emergence, Environment and translational research, Université de Paris Cité, Inserm, IRSL
- Michiko Niwa-Kawakita
- Université Paris Cité, Inserm, CNRS, GenCellDis, Institut de Recherche Saint-Louis
- Pierre Bercier
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Domitille Rérolle
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Pierre Therizols
- Université Paris Cité, Inserm, CNRS, GenCellDis, Institut de Recherche Saint-Louis
- Emmanuelle Fabre
- Université Paris Cité, Inserm, CNRS, GenCellDis, Institut de Recherche Saint-Louis
- Alfred C. O. Vertegaal
- Department of Cell and Chemical Biology, Leiden University Medical Center (LUMC)
- Hugues de Thé
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- Valérie Lallemand-Breitenbach
- Center for Interdisciplinary Research in Biology (CIRB), Collège de France, PSL research university, Inserm, Cnrs
- DOI
- https://doi.org/10.1038/s41467-022-33147-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Here the authors identify novel PML-partners and demonstrate that PML NBs control their sumoylation and that PML-controlled sumoylation of transcriptional regulators maintains the embryonic stem cell transcriptome and transposable element silencing.
