Trichomonacidal Activity of 3,3′-Diindolylmethane (DIM) Is Additive to Metronidazole (MTZ) In Vitro, Supporting Future Oral/Topical Use

Alexandra Ibáñez-Escribano; Leyre Pernaute Lau; Juan José Nogal-Ruiz; Alicia Gómez-Barrio; Jose Antonio Escario; Michael A. Zeligs

doi:10.3390/proceedings1060645

Proceedings (Oct 2017)

Trichomonacidal Activity of 3,3′-Diindolylmethane (DIM) Is Additive to Metronidazole (MTZ) In Vitro, Supporting Future Oral/Topical Use

Alexandra Ibáñez-Escribano,
Leyre Pernaute Lau,
Juan José Nogal-Ruiz,
Alicia Gómez-Barrio,
Jose Antonio Escario,
Michael A. Zeligs

Affiliations

Alexandra Ibáñez-Escribano: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Leyre Pernaute Lau: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Juan José Nogal-Ruiz: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Alicia Gómez-Barrio: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Jose Antonio Escario: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
Michael A. Zeligs: BioResponse LLC., P.O. Box 288 Boulder, CO 80306, USA

DOI: https://doi.org/10.3390/proceedings1060645
Journal volume & issue: Vol. 1, no. 6
p. 645

Abstract

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New, safe, well tolerated, and versatile anti-trichomonal agents for oral and topical use are needed to combat spreading resistance of Trichomonas vaginalis to metronidazole (MTZ). [...]

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Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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