Efficacy and Tolerance of Rezonizate in Complex with Fluoroquinolones or Mycobutin on a Model of Experimental Murine Tuberculosis

Abstract

The efficacy of rezonizate, a novel antituberculosis drug, in combination with fluoroquinolones or mycobutin was studied in experiments on mice infected with Mycobacterium tuberculosis. By the pathomorphological and microbiological criteria, the highest therapeutic effect was observed when rezonizate was used in combination with levofloxacin, the lowest effect was produced by rezonizate combination with gatifloxacin.

Keywords

• tuberculosis
• mice
• rezonizate
• fluoroquinolones
• mycobutin