WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Uda Y. Ho; Chun-Wei Allen Feng; Yvonne Y. Yeap; Amanda L. Bain; Zhe Wei; Belal Shohayeb; Melissa E. Reichelt; Hayden Homer; Kum Kum Khanna; Josephine Bowles; Dominic C. H. Ng

doi:10.1038/s42003-021-02171-5

Communications Biology (May 2021)

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Uda Y. Ho,
Chun-Wei Allen Feng,
Yvonne Y. Yeap,
Amanda L. Bain,
Zhe Wei,
Belal Shohayeb,
Melissa E. Reichelt,
Hayden Homer,
Kum Kum Khanna,
Josephine Bowles,
Dominic C. H. Ng

Affiliations

Uda Y. Ho: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Chun-Wei Allen Feng: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Yvonne Y. Yeap: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Amanda L. Bain: QIMR Berghofer Medical Research Institute
Zhe Wei: UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland
Belal Shohayeb: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Melissa E. Reichelt: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Hayden Homer: UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland
Kum Kum Khanna: QIMR Berghofer Medical Research Institute
Josephine Bowles: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland
Dominic C. H. Ng: School of Biomedical Sciences, Faculty of Medicine, The University of Queensland

DOI: https://doi.org/10.1038/s42003-021-02171-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Uda Ho et al find that loss of centriolar scaffold protein WDR62 in mouse testis leads to defects in spermatogenesis. They find that WDR62 deficiency leads to centriole underduplication in spermatocytes and delayed manchette removal in spermatids due to delayed Katanin p80 accumulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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