Hematology (Dec 2023)

A phase II study of lenalidomide and rituximab (R2) combination in patients with high-risk refractory/relapsed diffuse large B-cell lymphoma

  • Robin Noel,
  • Christophe Zemmour,
  • Catalina Montes de Oca,
  • Nawel Belmecheri,
  • Thérèse Aurran-Schleinitz,
  • Diane Coso,
  • Leonor Lopez Almeida,
  • Lénaïg Mescam,
  • Norbert Vey,
  • Jean Sébastien Bladé,
  • Borhane Slama,
  • Reda Bouabdallah,
  • Jean-Marc Schiano de Colella

DOI
https://doi.org/10.1080/16078454.2023.2207948
Journal volume & issue
Vol. 28, no. 1

Abstract

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ABSTRACTRelapsed/Refractory Diffuse Large B Cell Lymphoma have a dismal prognosis in need of innovative treatments. This prospective phase 2 study enrolled 32 patients between 2013 and 2017 with Relapsed/Refractory Diffuse Large B Cell Lymphoma treated with Rituximab and Lenalidomide (R2). Median age was 69 years (40–86), 90.1% had received at least 2 prior lines of treatment, 81% were defined as having High Risk disease according to our criteria and ECOG performance status was > 2 in 51.6%. Patients received a median number of 2 cycles of R2 (1–12). With a median follow up of 22.6 months, the objective response rate was 12.5%. Median progression free survival was 2.6 months (95% CI, [1.7–2.9]) and median overall survival was 9.3 months (95% CI, [5.1–Not estimable]). This study therefore did not achieve its primary endpoint and the R2 regimen cannot be recommended in Relapsed/Refractory Diffuse Large B Cell Lymphoma patients with High Risk features.

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