A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

Hayden Weng Siong Tan; Guang Lu; Han Dong; Yik-Lam Cho; Auginia Natalia; Liming Wang; Charlene Chan; Dennis Kappei; Reshma Taneja; Shuo-Chien Ling; Huilin Shao; Shih-Yin Tsai; Wen-Xing Ding; Han-Ming Shen

doi:10.1038/s41467-022-31213-7

Nature Communications (Jun 2022)

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

Hayden Weng Siong Tan,
Guang Lu,
Han Dong,
Yik-Lam Cho,
Auginia Natalia,
Liming Wang,
Charlene Chan,
Dennis Kappei,
Reshma Taneja,
Shuo-Chien Ling,
Huilin Shao,
Shih-Yin Tsai,
Wen-Xing Ding,
Han-Ming Shen

Affiliations

Hayden Weng Siong Tan: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Guang Lu: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Han Dong: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Yik-Lam Cho: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Auginia Natalia: Institute for Health Innovation & Technology, National University of Singapore
Liming Wang: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Charlene Chan: Cancer Science Institute of Singapore, National University of Singapore
Dennis Kappei: Cancer Science Institute of Singapore, National University of Singapore
Reshma Taneja: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Shuo-Chien Ling: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Huilin Shao: Institute for Health Innovation & Technology, National University of Singapore
Shih-Yin Tsai: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Wen-Xing Ding: Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center
Han-Ming Shen: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-31213-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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