MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
Javaid Ahmad Wani,
Sabhiya Majid,
Zuha Imtiyaz,
Muneeb U. Rehman,
Rana M. Alsaffar,
Naveed Nazir Shah,
Sultan Alshehri,
Mohammed M. Ghoneim,
Syed Sarim Imam
Affiliations
Javaid Ahmad Wani
Department of Biochemistry, Government Medical College (GMC-Srinagar), Karan Nagar, Srinagar 190010, J&K, India
Sabhiya Majid
Department of Biochemistry, Government Medical College (GMC-Srinagar), Karan Nagar, Srinagar 190010, J&K, India
Zuha Imtiyaz
Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
Muneeb U. Rehman
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Rana M. Alsaffar
Department of Pharmacology & Toxicology, College of Pharmacy Girls Section, Prince Sattam Bin Abdulaziz University, P.O. Box-173, Al-Kharj 11942, Saudi Arabia
Naveed Nazir Shah
Department of Pulmonary Medicine, Government Medical College (GMC-Srinagar), Karan Nagar, Srinagar 190010, J&K, India
Sultan Alshehri
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Mohammed M. Ghoneim
Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh 13713, Saudi Arabia
Syed Sarim Imam
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.
