Simvastatin Promotes Osteogenesis and Angiogenesis through Mediating Immunology of Senescent Macrophages

Abstract

In this article, we mainly investigated the effects of different simvastatin concentrations on the biological behavior of senescent macrophages and the immune microenvironment mediated by them on osteogenic and angiogenic functions. The feasibility of loading simvastatin on titanium surfaces to mediate the function of senescent macrophages was also explored. The results show that when the concentration of the drug was 0.1 μmol/L, it promoted the proliferation of macrophages and polarized them to pro-healing M2 phenotype, which is beneficial for macrophages to create an immune microenvironment promoting osteogenesis and angiogenesis. The chitosan/gelatin coating constructed on titanium surface could load and release simvastatin, promoting the viability and proliferation of senescent macrophages.

Keywords

• simvastatin
• macrophages
• titanium
• immune microenvironment
• osteogenesis
• angiogenesis