Emerging Infectious Diseases (Jan 2014)

Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

  • Jean Yves Douet,
  • Saima Zafar,
  • Armand Perret-Liaudet,
  • Caroline Lacroux,
  • Séverine Lugan,
  • Naima Aron,
  • Herve Cassard,
  • Claudia Ponto,
  • Fabien Corbière,
  • Juan Maria Torres,
  • Inga Zerr,
  • Olivier Andreoletti

DOI
https://doi.org/10.3201/eid2001.130353
Journal volume & issue
Vol. 20, no. 1
pp. 114 – 117

Abstract

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We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.

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