Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes

Yue Yu; Xi Yang; Sheethal Reghu; Sunil C. Kaul; Renu Wadhwa; Eijiro Miyako

doi:10.1038/s41467-020-17768-3

Nature Communications (Aug 2020)

Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes

Yue Yu,
Xi Yang,
Sheethal Reghu,
Sunil C. Kaul,
Renu Wadhwa,
Eijiro Miyako

Affiliations

Yue Yu: Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology
Xi Yang: Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology
Sheethal Reghu: Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology
Sunil C. Kaul: AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), Cellular and Molecular Biotechnology Research Institute, AIST
Renu Wadhwa: AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), Cellular and Molecular Biotechnology Research Institute, AIST
Eijiro Miyako: Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-17768-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Cancer stem cells (CSCs) are known to induce chemotherapy resistance, and cause tumour relapse and metastasis. Here, the authors develop photoactive nanocarbon complexes with second near-infrared photothermal ability to target cancer cells overexpressing the receptor TRPV2 and show it to suppress CSCs through dysregulation of the Wnt/β-catenin signalling pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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