Nature Communications (Aug 2018)
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
- David Olagnier,
- Aske M. Brandtoft,
- Camilla Gunderstofte,
- Nikolaj L. Villadsen,
- Christian Krapp,
- Anne L. Thielke,
- Anders Laustsen,
- Suraj Peri,
- Anne Louise Hansen,
- Lene Bonefeld,
- Jacob Thyrsted,
- Victor Bruun,
- Marie B. Iversen,
- Lin Lin,
- Virginia M. Artegoitia,
- Chenhe Su,
- Long Yang,
- Rongtuan Lin,
- Siddharth Balachandran,
- Yonglun Luo,
- Mette Nyegaard,
- Bernadette Marrero,
- Raphaela Goldbach-Mansky,
- Mona Motwani,
- Dylan G. Ryan,
- Katherine A. Fitzgerald,
- Luke A. O’Neill,
- Anne K. Hollensen,
- Christian K. Damgaard,
- Frank v. de Paoli,
- Hanne C. Bertram,
- Martin R. Jakobsen,
- Thomas B. Poulsen,
- Christian K. Holm
Affiliations
- David Olagnier
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Aske M. Brandtoft
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Camilla Gunderstofte
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Nikolaj L. Villadsen
- Department of Chemistry, Aarhus University
- Christian Krapp
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Anne L. Thielke
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Anders Laustsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Suraj Peri
- Fox Chase Cancer Center
- Anne Louise Hansen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Lene Bonefeld
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Jacob Thyrsted
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Victor Bruun
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Marie B. Iversen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Lin Lin
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Virginia M. Artegoitia
- Department of Food Science, Aarhus University
- Chenhe Su
- Lady Davis Institute-Jewish General Hospital, McGill University, Division of Experimental Medicine
- Long Yang
- Lady Davis Institute-Jewish General Hospital, McGill University, Division of Experimental Medicine
- Rongtuan Lin
- Lady Davis Institute-Jewish General Hospital, McGill University, Division of Experimental Medicine
- Siddharth Balachandran
- Fox Chase Cancer Center
- Yonglun Luo
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Mette Nyegaard
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Bernadette Marrero
- Translational Autoinflammatory Diseases Studies, NIAID
- Raphaela Goldbach-Mansky
- Translational Autoinflammatory Diseases Studies, NIAID
- Mona Motwani
- Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School
- Dylan G. Ryan
- School of biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, College Green
- Katherine A. Fitzgerald
- Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School
- Luke A. O’Neill
- School of biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, College Green
- Anne K. Hollensen
- Department of Molecular Biology and Genetics, Aarhus University
- Christian K. Damgaard
- Department of Molecular Biology and Genetics, Aarhus University
- Frank v. de Paoli
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Hanne C. Bertram
- Department of Food Science, Aarhus University
- Martin R. Jakobsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Thomas B. Poulsen
- Department of Chemistry, Aarhus University
- Christian K. Holm
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- DOI
- https://doi.org/10.1038/s41467-018-05861-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells.
