Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Ruofan Yu; Xiaohua Cao; Luyang Sun; Jun-yi Zhu; Brian M Wasko; Wei Liu; Emeline Crutcher; Haiying Liu; Myeong Chan Jo; Lidong Qin; Matt Kaeberlein; Zhe Han; Weiwei Dang

doi:10.1038/s41467-021-22257-2

Nature Communications (Mar 2021)

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Ruofan Yu,
Xiaohua Cao,
Luyang Sun,
Jun-yi Zhu,
Brian M Wasko,
Wei Liu,
Emeline Crutcher,
Haiying Liu,
Myeong Chan Jo,
Lidong Qin,
Matt Kaeberlein,
Zhe Han,
Weiwei Dang

Affiliations

Ruofan Yu: Department of Molecular and Human Genetics, Baylor College of Medicine
Xiaohua Cao: Department of Molecular and Human Genetics, Baylor College of Medicine
Luyang Sun: Department of Molecular and Human Genetics, Baylor College of Medicine
Jun-yi Zhu: Center for Precision Disease Modeling, University of Maryland School of Medicine
Brian M Wasko: Department of Pathology, University of Washington
Wei Liu: Department of Molecular and Human Genetics, Baylor College of Medicine
Emeline Crutcher: Department of Molecular and Human Genetics, Baylor College of Medicine
Haiying Liu: Department of Molecular and Human Genetics, Baylor College of Medicine
Myeong Chan Jo: Innovative BioChips
Lidong Qin: Department of Nanomedicine, Houston Methodist Research Institute
Matt Kaeberlein: Department of Pathology, University of Washington
Zhe Han: Center for Precision Disease Modeling, University of Maryland School of Medicine
Weiwei Dang: Department of Molecular and Human Genetics, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-021-22257-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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