LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

Abstract

How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.