Changes in heparin- and lectin-binding activity of fibronectin in proliferative blood diseases

Abstract

Fibronectin concentration, its heparin-binding activity and interaction with Lens Culinaris Agglutinin (LCA), Aleuria Aurantia Lectin (AAL) and Laburnum Anagyroides Agglutinin (LABA) in patients with erythremia and subleukemic myelosis were investigated. Reliable decreasing of concentration and heparin-binding activity of plasma fibronectin as well as a connection between its functional activity and lectin-affinity were detected. Increasing of the level of core fucose in N-glycans of fibronectin in proliferative blood diseases was revealed. Presence of fucose in O-glycans of fibronectin and dependence of fucosylation level of O-glycans in the glycoprotein on the type of pathological processes were proved.

Keywords

• fibronectin
• heparin
• lectin
• fucose
• erythremia
• subleukemic myelosis