Hematology (Dec 2022)

Clinical efficacy of recombinant human thrombopoietin combined with glucocorticoids in the treatment of immune thrombocytopenia

  • Jing-xin Zhou,
  • Ling Gao,
  • Nan Hu,
  • Zhi-Ling Yan,
  • Chun-ying Tian,
  • Jing Su,
  • Ji-Jin Qi,
  • Jun-shuai Yue,
  • Wen-tong Ma

DOI
https://doi.org/10.1080/16078454.2022.2121103
Journal volume & issue
Vol. 27, no. 1
pp. 1062 – 1068

Abstract

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Objective: Herein, we aimed to determine the clinical efficacy of recombinant human thrombopoietin (rhTPO) combined with glucocorticoids for treating immune thrombocytopenia (ITP).Methods: Clinical data of 87 patients with ITP admitted to our hospital were retrospectively analyzed, and patients were divided into two groups according to the treatment employed: 42 patients in the control group (CG) were prescribed glucocorticoids, and 45 patients in the study group (SG) received rhTPO combined with glucocorticoids.Results: The total effective treatment rate in the SG (95.56%) was higher than that in the CG (76.19%) (P 50 × 109/L faster and required fewer PLT transfusions than the CG (P 0.05).Conclusion: rhTPO combined with glucocorticoids for treating ITP can effectively enhance the therapeutic effect, regulate the T lymphocyte subpopulation, rapidly increase the PLT level, and induce no significant effect on the coagulation function of patients, with good safety and high clinical promotion value.

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