Production Process Optimization of Recombinant Erwinia carotovora l‑Asparaginase II in Escherichia coli Fed-Batch Cultures and Analysis of Antileukemic Potential

• Bruna Coelho de Andrade,
• Gaby Renard,
• Adriano Gennari,
• Leonardo Luís Artico,
• José Ricardo Teixeira Júnior,
• Daniel Kuhn,
• Priscila Pini Zenatti Salles,
• Claucia Fernada Volken de Souza,
• Gustavo Roth,
• Jocelei Maria Chies,
• José Andrés Yunes,
• Luiz Augusto Basso

Affiliations

Bruna Coelho de Andrade

National Institute of Science and Technology in Tuberculosis, Research Center for Molecular and Functional Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Gaby Renard

Quatro G Pesquisa & Desenvolvimento Ltd., Porto Alegre, Rio Grande do Sul, Brazil

Adriano Gennari

Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul, Brazil

Leonardo Luís Artico

Centro Infantil Boldrini, Campinas, São Paulo, Brazil

José Ricardo Teixeira Júnior

Centro Infantil Boldrini, Campinas, São Paulo, Brazil

Daniel Kuhn

Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul, Brazil

Priscila Pini Zenatti Salles

Centro Infantil Boldrini, Campinas, São Paulo, Brazil

Claucia Fernada Volken de Souza

Food Biotechnology Laboratory, Biotechnology Graduate Program, University of Vale do Taquari (UNIVATES), Lajeado, Rio Grande do Sul, Brazil

Gustavo Roth

Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

Jocelei Maria Chies

Quatro G Pesquisa & Desenvolvimento Ltd., Porto Alegre, Rio Grande do Sul, Brazil

José Andrés Yunes

Centro Infantil Boldrini, Campinas, São Paulo, Brazil

Luiz Augusto Basso

National Institute of Science and Technology in Tuberculosis, Research Center for Molecular and Functional Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil