Autologous conditioned serum applications in the treatment of musculoskeletal diseases: a narrative review

Abstract

Aim: Autologous conditioned serum has been studied as a treatment option in musculoskeletal disorders and resulted in varying outcomes. This study aims to pool the current data on this matter. Materials & methods: Major databases were searched for the topics, and after screening the results, the final 21 papers (level of evidence I or II) were included. Results & conclusion: This study showed a major focus of the literature on the effectiveness of autologous conditioned serum in osteoarthritis, in which there is much high-quality evidence suggesting its safety and efficacy. Also, some of the available experiments are assessing its application in tendinopathies and radiculopathies which, despite positive results, recommend further evaluations on this topic.

Keywords

• autologous conditioned serum
• Interleukin-1 receptor antagonist protein
• literature review
• musculoskeletal diseases
• orthokine
• osteoarthritis