Бюллетень сибирской медицины (Jan 2022)

Synaptic transmission molecules and their role in the pathogenesis of allergic rhinitis

  • A. V. Klimov,
  • O. V. Kalyuzhin,
  • V. V. Klimov,
  • O. A. Naidina

DOI
https://doi.org/10.20538/1682-0363-2021-4-143-152
Journal volume & issue
Vol. 20, no. 4
pp. 143 – 152

Abstract

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Immune cells and molecules, as well as synaptic transmission molecules play a regulatory role in the communication pathways of the entire body when it is necessary to engage all body resources in the fight against infections or tumor cells wherever they appear. In potential allergy, the neuroimmune network controls allergen tolerance maintenance at both local and systemic levels.The review focuses on different neurotransmitters and our understanding of a balance and imbalance between the immune system and the nervous system in allergic inflammation, including allergic rhinitis. However, the pathogenesis of the two endotypes of rhinitis (conventional allergic rhinitis and local allergic rhinitis) and the impact of the neuroimmune network on it remain unresolved.

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