Nature Communications (Jul 2019)
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
- Francesca Bufalieri,
- Paola Infante,
- Flavia Bernardi,
- Miriam Caimano,
- Paolo Romania,
- Marta Moretti,
- Ludovica Lospinoso Severini,
- Julie Talbot,
- Ombretta Melaiu,
- Mirella Tanori,
- Laura Di Magno,
- Diana Bellavia,
- Carlo Capalbo,
- Stéphanie Puget,
- Enrico De Smaele,
- Gianluca Canettieri,
- Daniele Guardavaccaro,
- Luca Busino,
- Angelo Peschiaroli,
- Simonetta Pazzaglia,
- Giuseppe Giannini,
- Gerry Melino,
- Franco Locatelli,
- Alberto Gulino,
- Olivier Ayrault,
- Doriana Fruci,
- Lucia Di Marcotullio
Affiliations
- Francesca Bufalieri
- Department of Molecular Medicine, University La Sapienza
- Paola Infante
- Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia
- Flavia Bernardi
- Department of Molecular Medicine, University La Sapienza
- Miriam Caimano
- Department of Molecular Medicine, University La Sapienza
- Paolo Romania
- Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, IRCCS
- Marta Moretti
- Department of Molecular Medicine, University La Sapienza
- Ludovica Lospinoso Severini
- Department of Molecular Medicine, University La Sapienza
- Julie Talbot
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Ombretta Melaiu
- Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, IRCCS
- Mirella Tanori
- Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l’Energia e lo Sviluppo Economico Sostenibile (ENEA)
- Laura Di Magno
- Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia
- Diana Bellavia
- Department of Molecular Medicine, University La Sapienza
- Carlo Capalbo
- Department of Molecular Medicine, University La Sapienza
- Stéphanie Puget
- Department of Pediatric Neurosurgery, Necker University Hospital, University Paris Descartes, Sorbonne Paris Cité
- Enrico De Smaele
- Department of Experimental Medicine, University La Sapienza
- Gianluca Canettieri
- Department of Molecular Medicine, University La Sapienza
- Daniele Guardavaccaro
- Department of Biotechnology, University of Verona
- Luca Busino
- Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania
- Angelo Peschiaroli
- National Research Council of Italy CNR, Institute of Translational Pharmacology (IFT)
- Simonetta Pazzaglia
- Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l’Energia e lo Sviluppo Economico Sostenibile (ENEA)
- Giuseppe Giannini
- Department of Molecular Medicine, University La Sapienza
- Gerry Melino
- MRC Toxicology Unit, University of Cambridge
- Franco Locatelli
- Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, IRCCS
- Alberto Gulino
- Department of Molecular Medicine, University La Sapienza
- Olivier Ayrault
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Doriana Fruci
- Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, IRCCS
- Lucia Di Marcotullio
- Department of Molecular Medicine, University La Sapienza
- DOI
- https://doi.org/10.1038/s41467-019-11093-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.
