Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

• Natalie J. Welsh,
• Christina A. Gewinner,
• Kavita Mistry,
• Mumta Koglin,
• Juniebel Cooke,
• Matthew Butler,
• Ben Powney,
• Malcolm Roberts,
• James M. Staddon,
• Anthony H. V. Schapira

Affiliations

Natalie J. Welsh

Eisai-UCL Drug Discovery and Development Collaboration, UCL Queen Square Institute of Neurology, School of Life Sciences and Medicine, University College London, London

Christina A. Gewinner

Eisai-UCL Drug Discovery and Development Collaboration, UCL Queen Square Institute of Neurology, School of Life Sciences and Medicine, University College London, London

Kavita Mistry

Neurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd, Hatfield, Hertfordshire

Mumta Koglin

Neurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd, Hatfield, Hertfordshire

Juniebel Cooke

Lysosomal Storage Disorders Unit, Royal Free Hospital, London

Matthew Butler

Eisai-UCL Drug Discovery and Development Collaboration, UCL Queen Square Institute of Neurology, School of Life Sciences and Medicine, University College London, London

Ben Powney

Neurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd, Hatfield, Hertfordshire

Malcolm Roberts

Neurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd, Hatfield, Hertfordshire

James M. Staddon

Neurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd, Hatfield, Hertfordshire

Anthony H. V. Schapira

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK