Influence of occupational exposure to pigs or chickens on human gut microbiota composition in Thailand

Duangdao Sudatip; Nadezda Mostacci; Visanu Thamlikitkul; Anne Oppliger; Markus Hilty

One Health (Dec 2022)

Influence of occupational exposure to pigs or chickens on human gut microbiota composition in Thailand

Duangdao Sudatip,
Nadezda Mostacci,
Visanu Thamlikitkul,
Anne Oppliger,
Markus Hilty

Affiliations

Duangdao Sudatip: Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, Bangkok, Thailand; Institute for Infectious Diseases, University of Bern, Bern, Switzerland; Department of Occupational and Environmental Health, Unisanté, University of Lausanne, Lausanne, Switzerland; Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand
Nadezda Mostacci: Institute for Infectious Diseases, University of Bern, Bern, Switzerland; Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, Bangkok, Thailand
Visanu Thamlikitkul: Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Anne Oppliger: Department of Occupational and Environmental Health, Unisanté, University of Lausanne, Lausanne, Switzerland
Markus Hilty: Institute for Infectious Diseases, University of Bern, Bern, Switzerland; Corresponding author at: Institute for Infectious Diseases, University of Bern, Friedbühlstrasse 51, Bern 3001, Switzerland.

Journal volume & issue: Vol. 15
p. 100463

Abstract

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Pig farming's influence on human gut microbiota has been observed previously, but its pervasiveness is unclear. We therefore aimed at studying whether pig farming influenced human gut microbiota composition in Thailand and whether poultry farming did too.We collected human stool samples (71 pig farmers, 131 chicken farmers, 55 non-farmers) for 16S rRNA sequencing and performed subsequent DADA2 analyses of amplicon sequence variants.We found that Alpha diversity values were highest among chicken farmers. Relative abundances of Prevotellaceae were significantly higher among pig farmers than among chicken farmers and non-farmers (p < 0.001). Beta diversity plots revealed different clustering according to occupation. The presence or absence of antimicrobial-resistant Escherichia coli was not associated with changes in gut microbiota composition.In conclusion, occupation was the strongest factor influencing gut microbiota composition in Thailand. We hypothesize that Prevotellaceae amplicon sequence variants are transmitted from pigs to pig farmers.

Published in One Health

ISSN: 2352-7714 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: https://www.journals.elsevier.com/one-health

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