RUDN Journal of Medicine (Dec 2009)
The influence citokines in relapses of purulently complications at the diabetic foots and opportunities immunokorection
Abstract
Studying of influence citokines in relapses of purulently complications at patients with a diabetic foots will allow to understand their function in development of pathological process. At 35 patients investigated levels: IL-1b, IL-4, IL-6, IL-8, IL-10 and FNO-a, ИНФ-γ in day of operation, for 3, 5, 7, 11, 21-22 day. There is an stimulaition only IL-8 up to 182,75 pg/ml in the first day before operation - to growth up to 245,5 pg /ml by 5 day and with decrease to 40,09 pg /ml by 21-22 days. With the purpose immunomodulation used polioksidoni at 12 patients. The effect of a preparation was shown in stimulaition citokines. 12 operations keeping to foots are executed. Use polioksidoni treatment of relapses of purulently complications is recommended at a diabetic foots.