Communications Biology (May 2022)
An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
- Henri-Baptiste Marjault,
- Ola Karmi,
- Ke Zuo,
- Dorit Michaeli,
- Yael Eisenberg-Domovich,
- Giulia Rossetti,
- Benoit de Chassey,
- Jacky Vonderscher,
- Ioav Cabantchik,
- Paolo Carloni,
- Ron Mittler,
- Oded Livnah,
- Eric Meldrum,
- Rachel Nechushtai
Affiliations
- Henri-Baptiste Marjault
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Ola Karmi
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Ke Zuo
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Dorit Michaeli
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Yael Eisenberg-Domovich
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Giulia Rossetti
- Department of Physics, RWTH Aachen University
- Benoit de Chassey
- ENYO‐Pharma, Bioserra 1
- Jacky Vonderscher
- ENYO‐Pharma, Bioserra 1
- Ioav Cabantchik
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Paolo Carloni
- Department of Physics, RWTH Aachen University
- Ron Mittler
- Department of Surgery, University of Missouri School of Medicine, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center, University of Missouri
- Oded Livnah
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- Eric Meldrum
- ENYO‐Pharma, Bioserra 1
- Rachel Nechushtai
- The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem
- DOI
- https://doi.org/10.1038/s42003-022-03393-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 9
Abstract
Marjault et al. report two crystal structures of a drug molecule bound to NEET proteins mNT and NAF-1 and the effects of this molecule on diabetic mice, suggesting an approach for reducing mitochondrial iron and ROS levels in diabetic patients.
