Nature Communications (Jan 2021)
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
- Ayesha A. Shafi,
- Chris M. McNair,
- Jennifer J. McCann,
- Mohammed Alshalalfa,
- Anton Shostak,
- Tesa M. Severson,
- Yanyun Zhu,
- Andre Bergman,
- Nicolas Gordon,
- Amy C. Mandigo,
- Saswati N. Chand,
- Peter Gallagher,
- Emanuela Dylgjeri,
- Talya S. Laufer,
- Irina A. Vasilevskaya,
- Matthew J. Schiewer,
- Michael Brunner,
- Felix Y. Feng,
- Wilbert Zwart,
- Karen E. Knudsen
Affiliations
- Ayesha A. Shafi
- Department of Cancer Biology, Thomas Jefferson University
- Chris M. McNair
- Department of Cancer Biology, Thomas Jefferson University
- Jennifer J. McCann
- Department of Cancer Biology, Thomas Jefferson University
- Mohammed Alshalalfa
- Department of Radiation Oncology, University of California at San Francisco
- Anton Shostak
- Biochemistry Center, University of Heidelberg
- Tesa M. Severson
- Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute
- Yanyun Zhu
- Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute
- Andre Bergman
- Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute
- Nicolas Gordon
- Department of Cancer Biology, Thomas Jefferson University
- Amy C. Mandigo
- Department of Cancer Biology, Thomas Jefferson University
- Saswati N. Chand
- Department of Cancer Biology, Thomas Jefferson University
- Peter Gallagher
- Department of Cancer Biology, Thomas Jefferson University
- Emanuela Dylgjeri
- Department of Cancer Biology, Thomas Jefferson University
- Talya S. Laufer
- Department of Cancer Biology, Thomas Jefferson University
- Irina A. Vasilevskaya
- Department of Cancer Biology, Thomas Jefferson University
- Matthew J. Schiewer
- Department of Cancer Biology, Thomas Jefferson University
- Michael Brunner
- Biochemistry Center, University of Heidelberg
- Felix Y. Feng
- Department of Radiation Oncology, University of California at San Francisco
- Wilbert Zwart
- Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute
- Karen E. Knudsen
- Department of Cancer Biology, Thomas Jefferson University
- DOI
- https://doi.org/10.1038/s41467-020-20513-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Cryptochrome 1 (CRY1) is a transcriptional coregulator associated with the circadian clock. Here the authors reveal that CRY1 is hormone-regulated, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation.
