Communications Physics (Nov 2022)

Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis

  • Francesca Palermo,
  • Nicola Pieroni,
  • Alessia Sanna,
  • Benedetta Parodi,
  • Consuelo Venturi,
  • Ginevra Begani Provinciali,
  • Lorenzo Massimi,
  • Laura Maugeri,
  • Gian Paolo Marra,
  • Elena Longo,
  • Lorenzo D’Amico,
  • Giulia Saccomano,
  • Jonathan Perrin,
  • Giuliana Tromba,
  • Inna Bukreeva,
  • Michela Fratini,
  • Giuseppe Gigli,
  • Nicole Kerlero de Rosbo,
  • Alessia Cedola

DOI
https://doi.org/10.1038/s42005-022-01070-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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X-ray phase-contrast tomography offers a highly sensitive 3D imaging approach to investigate different disease-relevant networks at levels ranging from single cell through to intact organ. The authors present a concomitant study of the evolution of tissue damage and inflammation in different organs affected by the disease in the murine model for multiple sclerosis.