Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166

Henri-François Renard; François Tyckaert; Cristina Lo Giudice; Thibault Hirsch; Cesar Augusto Valades-Cruz; Camille Lemaigre; Massiullah Shafaq-Zadah; Christian Wunder; Ruddy Wattiez; Ludger Johannes; Pierre van der Bruggen; David Alsteens; Pierre Morsomme

doi:10.1038/s41467-020-15303-y

Nature Communications (Mar 2020)

Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166

Henri-François Renard,
François Tyckaert,
Cristina Lo Giudice,
Thibault Hirsch,
Cesar Augusto Valades-Cruz,
Camille Lemaigre,
Massiullah Shafaq-Zadah,
Christian Wunder,
Ruddy Wattiez,
Ludger Johannes,
Pierre van der Bruggen,
David Alsteens,
Pierre Morsomme

Affiliations

Henri-François Renard: UCLouvain, Louvain Institute of Biomolecular Science and Technology, Group of Molecular Physiology
François Tyckaert: UCLouvain, Louvain Institute of Biomolecular Science and Technology, Group of Molecular Physiology
Cristina Lo Giudice: UCLouvain, Louvain Institute of Biomolecular Science and Technology, NanoBiophysics lab
Thibault Hirsch: UCLouvain, de Duve Institute
Cesar Augusto Valades-Cruz: Institut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS
Camille Lemaigre: UCLouvain, Louvain Institute of Biomolecular Science and Technology, Group of Molecular Physiology
Massiullah Shafaq-Zadah: Institut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS
Christian Wunder: Institut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS
Ruddy Wattiez: UMons, Research Institute for Biosciences, Proteomics and Microbiology Lab
Ludger Johannes: Institut Curie, PSL Research University, Cellular and Chemical Biology unit, U1143 INSERM, UMR3666 CNRS
Pierre van der Bruggen: UCLouvain, de Duve Institute
David Alsteens: UCLouvain, Louvain Institute of Biomolecular Science and Technology, NanoBiophysics lab
Pierre Morsomme: UCLouvain, Louvain Institute of Biomolecular Science and Technology, Group of Molecular Physiology

DOI: https://doi.org/10.1038/s41467-020-15303-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

How and which cell surface molecules are taken up by clathrin-independent endocytosis is an ongoing area of research. Here, the authors show that the tumor marker CD166 is a clathrin-independent cargo that is taken up by endophilin-A3 and galectin-8, which regulates cancer cell migration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal