Identification of osteogenic progenitor cell-targeted peptides that augment bone formation

Min Jiang; Ruiwu Liu; Lixian Liu; Alexander Kot; Xueping Liu; Wenwu Xiao; Junjing Jia; Yuanpei Li; Kit S. Lam; Wei Yao

doi:10.1038/s41467-020-17417-9

Nature Communications (Aug 2020)

Identification of osteogenic progenitor cell-targeted peptides that augment bone formation

Min Jiang,
Ruiwu Liu,
Lixian Liu,
Alexander Kot,
Xueping Liu,
Wenwu Xiao,
Junjing Jia,
Yuanpei Li,
Kit S. Lam,
Wei Yao

Affiliations

Min Jiang: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center
Ruiwu Liu: Department of Biochemistry and Molecular Medicine, The University of California at Davis Medical Center
Lixian Liu: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center
Alexander Kot: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center
Xueping Liu: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center
Wenwu Xiao: Department of Biochemistry and Molecular Medicine, The University of California at Davis Medical Center
Junjing Jia: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center
Yuanpei Li: Department of Biochemistry and Molecular Medicine, The University of California at Davis Medical Center
Kit S. Lam: Department of Biochemistry and Molecular Medicine, The University of California at Davis Medical Center
Wei Yao: Center for Musculoskeletal Health, Department of Internal Medicine, The University of California at Davis Medical Center

DOI: https://doi.org/10.1038/s41467-020-17417-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

Activation of osteogenic cells is essential for bone regeneration. Here, the authors screen a peptide library and identify 2 compounds that promote osteogenic progenitor cell differentiation in vitro, and show that they increase bone formation and fracture repair in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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