CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Charlotte A. James; Yuexin Xu; Melissa S. Aguilar; Lichen Jing; Erik D. Layton; Martine Gilleron; Adriaan J. Minnaard; Thomas J. Scriba; Cheryl L. Day; Edus H. Warren; David M. Koelle; Chetan Seshadri

doi:10.1038/s41467-021-27764-w

Nature Communications (Jan 2022)

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Charlotte A. James,
Yuexin Xu,
Melissa S. Aguilar,
Lichen Jing,
Erik D. Layton,
Martine Gilleron,
Adriaan J. Minnaard,
Thomas J. Scriba,
Cheryl L. Day,
Edus H. Warren,
David M. Koelle,
Chetan Seshadri

Affiliations

Charlotte A. James: Molecular Medicine and Mechanisms of Disease PhD Program (M3D), Department of Pathology, University of Washington
Yuexin Xu: Clinical Research Division, Fred Hutchinson Cancer Research Center
Melissa S. Aguilar: Department of Medicine, University of Washington
Lichen Jing: Department of Medicine, University of Washington
Erik D. Layton: Department of Medicine, University of Washington
Martine Gilleron: Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS
Adriaan J. Minnaard: Stratingh Institute for Chemistry, University of Groningen
Thomas J. Scriba: South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town
Cheryl L. Day: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University
Edus H. Warren: Molecular Medicine and Mechanisms of Disease PhD Program (M3D), Department of Pathology, University of Washington
David M. Koelle: Clinical Research Division, Fred Hutchinson Cancer Research Center
Chetan Seshadri: Department of Medicine, University of Washington

DOI: https://doi.org/10.1038/s41467-021-27764-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid antigens

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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