Effect of T-2 toxin on the activity of antioxidant enzymes and processes of lipid peroxidation in red blood cells of rats

Abstract

The effect of T-2 toxin on the processes of lipid peroxidation and the activity of antioxidant enzymes in erythrocytes of rats and the neutralizing effect of silica on T-2 toxin action were studied. An increase in concentration of diene conjugates (1–3 days) and TBA-active products (2–4 day experimental period) was established. Besides superoxide dismutase activity decreased in 1–3 days, and activity of catalase increased in 1–4 days of experimental period. Parameters approached the control values on the 5th day after administration of T-2 toxin. The obtained results indicate activation of lipid peroxidation and disturbance in functioning of certain enzymes of antioxidant system, suggesting a negative effect of T-2 toxin on the morpho-functional state of erythrocytes. Using aerosil together with toxicants normalized the above noted indicators and approached them to values similar to thase observed in control group of animals, suggesting the high sorption capacity of aerosil, towards T-2 toxin.

Keywords

• t-2 toxin
• tryhotethecenes mycotoxins
• antioxidant system
• lipid per­oxi­dation
• erythrocyte