Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)

Min Cheol Kim; Reiko Cullum; Ali M. S. Hebishy; Hala A. Mohamed; Ahmed H. I. Faraag; Nehad M. Salah; Mohamed S. Abdelfattah; William Fenical

doi:10.3390/antibiotics9050252

Antibiotics (May 2020)

Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)

Min Cheol Kim,
Reiko Cullum,
Ali M. S. Hebishy,
Hala A. Mohamed,
Ahmed H. I. Faraag,
Nehad M. Salah,
Mohamed S. Abdelfattah,
William Fenical

Affiliations

Min Cheol Kim: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Reiko Cullum: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Ali M. S. Hebishy: Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Hala A. Mohamed: Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Ahmed H. I. Faraag: Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Nehad M. Salah: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Mohamed S. Abdelfattah: Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
William Fenical: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA

DOI: https://doi.org/10.3390/antibiotics9050252
Journal volume & issue: Vol. 9, no. 5
p. 252

Abstract

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New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.

Published in Antibiotics

ISSN: 2079-6382 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.mdpi.com/journal/antibiotics

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