Mersaquinone, A New Tetracene Derivative from the Marine-Derived <i>Streptomyces</i> sp. EG1 Exhibiting Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)
Min Cheol Kim,
Reiko Cullum,
Ali M. S. Hebishy,
Hala A. Mohamed,
Ahmed H. I. Faraag,
Nehad M. Salah,
Mohamed S. Abdelfattah,
William Fenical
Affiliations
Min Cheol Kim
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Reiko Cullum
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Ali M. S. Hebishy
Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Hala A. Mohamed
Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Ahmed H. I. Faraag
Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Nehad M. Salah
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Mohamed S. Abdelfattah
Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
William Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.
