Classical Hodgkin’s Lymphoma Presenting as Acute Hepatic Failure—One Case Report

Abstract

A 20-year-old boy presenting daily febrile episodes was suspected to have developed acute hepatic failure. Serologic tests ruled out infectious and autoimmune causes apart from drug toxicity. During clinical examinations, he was found to have generalized enlarged lymph nodes that were then taken biopsy. It was diagnosed as classical Hodgkin’s lymphoma based on histological examination of the lymph node. A bone marrow biopsy showed marrow infi ltration by Hodgkin’s lymphoma with hemophagocytosis and secondary myelofibrosis. A percutaneous liver biopsy demonstrated hepatic involvement of the same disease. After an extensive work-up, the cause of liver failure was figure out to be only attributed to the involvement of the lymphoma. Hodgkin’s lymphoma as a cause of hepatic failure is rare and young patients diagnosed as Hodgkin’s lymphoma causing hepatic failure has been reported very rarely so far.

Keywords

• Hodgkin’s disease
• bone marrow
• liver failure
• acute