Communications Chemistry (Feb 2023)

1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes

  • Daisuke Tsuji,
  • Atsushi Nakayama,
  • Riko Yamamoto,
  • Shuji Nagano,
  • Takashi Taniguchi,
  • Ryota Sato,
  • Sangita Karanjit,
  • Naoki Muguruma,
  • Tetsuji Takayama,
  • Kohji Itoh,
  • Kosuke Namba

DOI
https://doi.org/10.1038/s42004-023-00838-0
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 11

Abstract

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Photoactive dyes can show promising cytotoxicity via reactive oxygen species generated by photoirradiation, however, the cytotoxicity of small molecule dyes is typically weak. Here, the authors develop 1,3a,6a-triazapentalene derivatives exhibiting selective and efficient photo-induced cytotoxicity.