MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

Abstract

It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calcium uptake capacity, neurotransmitter release properties and axon branching.