eJHaem (Feb 2024)

Autoimmune thrombotic thrombocytopenic purpura associated with disseminated sarcoidosis: A case report

  • Maxime Billotte,
  • Peter Eszto,
  • Benoît Thomas,
  • Pierre Groizard,
  • Pierre Perez,
  • Julien Campagne

DOI
https://doi.org/10.1002/jha2.848
Journal volume & issue
Vol. 5, no. 1
pp. 225 – 230

Abstract

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Abstract Sarcoidosis is an inflammatory disease known to be associated with multiple autoimmune disorders. There is a restricted number of descriptions of the association between sarcoidosis and autoimmune thrombotic thrombocytopenic purpura (aTTP). We present the case of a 63‐year‐old woman admitted to the hospital to investigate a possible sarcoidosis who had hemolytic anemia and thrombocytopenia, with low ADAMTS13 activity and anti‐ADAMTS13 antibodies, leading to a diagnosis of aTTP. Sarcoidosis was later confirmed and the two conditions evolved separately after 6 months, questioning the link between them. Clinicians should be aware of this rare cause of thrombocytopenia in patients with sarcoidosis, as aTTP is a life‐threatening condition.

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