Communications Biology (Jul 2021)
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells
- Peng Shang,
- Nadezda Stepicheva,
- Kenneth Teel,
- Austin McCauley,
- Christopher Scott Fitting,
- Stacey Hose,
- Rhonda Grebe,
- Meysam Yazdankhah,
- Sayan Ghosh,
- Haitao Liu,
- Anastasia Strizhakova,
- Joseph Weiss,
- Imran A. Bhutto,
- Gerard A. Lutty,
- Ashwath Jayagopal,
- Jiang Qian,
- José-Alain Sahel,
- J. Samuel Zigler,
- James T. Handa,
- Yuri Sergeev,
- Raju V. S. Rajala,
- Simon Watkins,
- Debasish Sinha
Affiliations
- Peng Shang
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Nadezda Stepicheva
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Kenneth Teel
- Dean McGee Eye Institute, University of Oklahoma Health Science Center
- Austin McCauley
- Dean McGee Eye Institute, University of Oklahoma Health Science Center
- Christopher Scott Fitting
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Stacey Hose
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Rhonda Grebe
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Meysam Yazdankhah
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Sayan Ghosh
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Haitao Liu
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Anastasia Strizhakova
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Joseph Weiss
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Imran A. Bhutto
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Gerard A. Lutty
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Ashwath Jayagopal
- Kodiak Sciences
- Jiang Qian
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- José-Alain Sahel
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- J. Samuel Zigler
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- James T. Handa
- Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Yuri Sergeev
- National Eye Institute, National Institutes of Health
- Raju V. S. Rajala
- Dean McGee Eye Institute, University of Oklahoma Health Science Center
- Simon Watkins
- Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine
- Debasish Sinha
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- DOI
- https://doi.org/10.1038/s42003-021-02386-6
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin network disruption which leads to polarity disruption and degeneration through PITP β/PLC signaling.
