Blood flow controls bone vascular function and osteogenesis

Saravana K. Ramasamy; Anjali P. Kusumbe; Maria Schiller; Dagmar Zeuschner; M. Gabriele Bixel; Carlo Milia; Jaba Gamrekelashvili; Anne Limbourg; Alexander Medvinsky; Massimo M. Santoro; Florian P. Limbourg; Ralf H. Adams

doi:10.1038/ncomms13601

Nature Communications (Dec 2016)

Blood flow controls bone vascular function and osteogenesis

Saravana K. Ramasamy,
Anjali P. Kusumbe,
Maria Schiller,
Dagmar Zeuschner,
M. Gabriele Bixel,
Carlo Milia,
Jaba Gamrekelashvili,
Anne Limbourg,
Alexander Medvinsky,
Massimo M. Santoro,
Florian P. Limbourg,
Ralf H. Adams

Affiliations

Saravana K. Ramasamy: Department of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Anjali P. Kusumbe: Department of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Maria Schiller: Department of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Dagmar Zeuschner: Electron Microscopy Unit, Max-Planck-Institute for Molecular Biomedicine
M. Gabriele Bixel: Department of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Carlo Milia: VIB Vesalius Research Center, KU Leuven
Jaba Gamrekelashvili: Department of Nephrology and Hypertension, Hannover Medical School
Anne Limbourg: Department of Plastic and Reconstructive Surgery, Hannover Medical School
Alexander Medvinsky: Research group Ontogeny of Haematopoietic Stem Cells, MRC Centre for Regenerative Medicine, University of Edinburgh
Massimo M. Santoro: VIB Vesalius Research Center, KU Leuven
Florian P. Limbourg: Department of Nephrology and Hypertension, Hannover Medical School
Ralf H. Adams: Department of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster

DOI: https://doi.org/10.1038/ncomms13601
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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