Nature Communications (May 2020)

A mechanistic account of serotonin’s impact on mood

  • Jochen Michely,
  • Eran Eldar,
  • Ingrid M. Martin,
  • Raymond J. Dolan

DOI
https://doi.org/10.1038/s41467-020-16090-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

The cognitive computational mechanisms underlying the antidepressant treatment response of SSRIs is not well understood. Here the authors show that SSRI treatment in healthy subjects for a week manifests as an amplification of the perception of positive outcomes when learning occurs in a positive mood setting.