Investigation of cytokine changes and deiminated proteins in LPS-induced inflammation in BV2 microglial cells

Abstract

Recent studies show that, deimination, one of the post-translational modifications, is associated with the neuro-degenerative disease process. Peptidyl arginine deiminases (PADs) catalyze deimination, PAD2 is particularly active in the central nervous system. This study aimed to examine the changes in proteins regarding deimination by inducing inflammation with lipopolysaccharide (LPS) in the BV2 microglial cell line and observe the changes in cytokines.

Keywords

• crp
• deimination
• neurodegeneration
• pad2
• western blot