Membranes are functionalized by a proteolipid code

Abstract

Abstract Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly of zones such as receptor clusters, protein-coated pits, lamellipodia, cell junctions, and membrane fusion sites is explained to occur through a protein-lipid code. This challenges the theory that lipids sort proteins after forming stable membrane subregions independently of proteins.

Keywords

• Fingerprint
• Integral membrane protein
• Lipidon
• Peripheral membrane protein
• Phosphoinositide
• Protein island