Nature Communications (Mar 2018)
Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes
- Sidika Tapsin,
- Miao Sun,
- Yang Shen,
- Huibin Zhang,
- Xin Ni Lim,
- Teodorus Theo Susanto,
- Siwy Ling Yang,
- Gui Sheng Zeng,
- Jasmine Lee,
- Alexander Lezhava,
- Ee Lui Ang,
- Lian Hui Zhang,
- Yue Wang,
- Huimin Zhao,
- Niranjan Nagarajan,
- Yue Wan
Affiliations
- Sidika Tapsin
- Stem Cell and Development Biology, Genome Institute of Singapore
- Miao Sun
- Computational and Systems Biology, Genome Institute of Singapore
- Yang Shen
- Computational and Systems Biology, Genome Institute of Singapore
- Huibin Zhang
- Metabolic Engineering Research Laboratory (MERL), Science and Engineering Institutes, Agency for Science, Technology, and Research (A*STAR)
- Xin Ni Lim
- Stem Cell and Development Biology, Genome Institute of Singapore
- Teodorus Theo Susanto
- Stem Cell and Development Biology, Genome Institute of Singapore
- Siwy Ling Yang
- Stem Cell and Development Biology, Genome Institute of Singapore
- Gui Sheng Zeng
- Institute of Molecular and Cell Biology, Proteos
- Jasmine Lee
- Institute of Molecular and Cell Biology, Proteos
- Alexander Lezhava
- Translational research group, Genome Institute of Singapore
- Ee Lui Ang
- Metabolic Engineering Research Laboratory (MERL), Science and Engineering Institutes, Agency for Science, Technology, and Research (A*STAR)
- Lian Hui Zhang
- Institute of Molecular and Cell Biology, Proteos
- Yue Wang
- Institute of Molecular and Cell Biology, Proteos
- Huimin Zhao
- Metabolic Engineering Research Laboratory (MERL), Science and Engineering Institutes, Agency for Science, Technology, and Research (A*STAR)
- Niranjan Nagarajan
- Computational and Systems Biology, Genome Institute of Singapore
- Yue Wan
- Stem Cell and Development Biology, Genome Institute of Singapore
- DOI
- https://doi.org/10.1038/s41467-018-03675-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Riboswitches recognize and respond to specific metabolites by altering gene expression. Here, the authors developed a high-throughput method (PARCEL) to experimentally identify RNA aptamers across transcriptomes.
