A Convenient, Rapid, Conventional Heating Route to MIDA Boronates

Andrew McGown; Anthony K. Edmonds; Daniel Guest; Verity L. Holmes; Chris Dadswell; Ramón González-Méndez; Charles A. I. Goodall; Mark C. Bagley; Barnaby W. Greenland; John Spencer

doi:10.3390/molecules27165052

Molecules (Aug 2022)

A Convenient, Rapid, Conventional Heating Route to MIDA Boronates

Andrew McGown,
Anthony K. Edmonds,
Daniel Guest,
Verity L. Holmes,
Chris Dadswell,
Ramón González-Méndez,
Charles A. I. Goodall,
Mark C. Bagley,
Barnaby W. Greenland,
John Spencer

Affiliations

Andrew McGown: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Anthony K. Edmonds: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Daniel Guest: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Verity L. Holmes: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Chris Dadswell: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Ramón González-Méndez: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Charles A. I. Goodall: Faculty of Engineering & Science, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Chatham ME4 4TB, UK
Mark C. Bagley: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
Barnaby W. Greenland: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK
John Spencer: Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK

DOI: https://doi.org/10.3390/molecules27165052
Journal volume & issue: Vol. 27, no. 16
p. 5052

Abstract

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A cheap, conventional, sealed heating reactor proved to be a useful alternative to a microwave reactor in the synthesis of a >20-member MIDA boronate library (MIDA = N-methyliminodiacetic acid). Reaction times were 10 min and work-ups were minimal, saving on energy and solvent usage.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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