Nature Communications (Jan 2022)
Helical structure motifs made searchable for functional peptide design
- Cheng-Yu Tsai,
- Emmanuel Oluwatobi Salawu,
- Hongchun Li,
- Guan-Yu Lin,
- Ting-Yu Kuo,
- Liyin Voon,
- Adarsh Sharma,
- Kai-Di Hu,
- Yi-Yun Cheng,
- Sobha Sahoo,
- Lutimba Stuart,
- Chih-Wei Chen,
- Yuan-Yu Chang,
- Yu-Lin Lu,
- Simai Ke,
- Christopher Llynard D. Ortiz,
- Bai-Shan Fang,
- Chen-Chi Wu,
- Chung-Yu Lan,
- Hua-Wen Fu,
- Lee-Wei Yang
Affiliations
- Cheng-Yu Tsai
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Emmanuel Oluwatobi Salawu
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Hongchun Li
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Guan-Yu Lin
- Institute of Molecular and Cellular Biology, National Tsing Hua University
- Ting-Yu Kuo
- Institute of Molecular and Cellular Biology, National Tsing Hua University
- Liyin Voon
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Adarsh Sharma
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Kai-Di Hu
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Yi-Yun Cheng
- Praexisio Taiwan Inc.
- Sobha Sahoo
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Lutimba Stuart
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Chih-Wei Chen
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Yuan-Yu Chang
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Yu-Lin Lu
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Simai Ke
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Christopher Llynard D. Ortiz
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- Bai-Shan Fang
- College of Chemistry and Chemical Engineering, Xiamen University
- Chen-Chi Wu
- Department of Otolaryngology, National Taiwan University Hospital
- Chung-Yu Lan
- Institute of Molecular and Cellular Biology, National Tsing Hua University
- Hua-Wen Fu
- Institute of Molecular and Cellular Biology, National Tsing Hua University
- Lee-Wei Yang
- Institute of Bioinformatics and Structural Biology, National Tsing Hua University
- DOI
- https://doi.org/10.1038/s41467-021-27655-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Here, we present TP-DB; a pattern-based search engine based on 1.67 million helices from the Protein Database (PDB). We demonstrate the utility of TP-DB in identifying microbe-specific antigens, as well as the design of antimicrobial peptides and Protein-protein interaction blockers.
