Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

Radhika Rawat; Elif Tunc-Ozcan; Tammy L. McGuire; Chian-Yu Peng; John A. Kessler

doi:10.1038/s41467-022-30386-5

Nature Communications (May 2022)

Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

Radhika Rawat,
Elif Tunc-Ozcan,
Tammy L. McGuire,
Chian-Yu Peng,
John A. Kessler

Affiliations

Radhika Rawat: Department of Neurology, Feinberg School of Medicine, Northwestern University
Elif Tunc-Ozcan: Department of Neurology, Feinberg School of Medicine, Northwestern University
Tammy L. McGuire: Department of Neurology, Feinberg School of Medicine, Northwestern University
Chian-Yu Peng: Department of Neurology, Feinberg School of Medicine, Northwestern University
John A. Kessler: Department of Neurology, Feinberg School of Medicine, Northwestern University

DOI: https://doi.org/10.1038/s41467-022-30386-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Rawat et al. demonstrate that activation of adult-born immature hippocampal neurons is necessary and sufficient for the acute antidepressant effects of low-dose ketamine in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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